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Sodium alginate-guar gum and carbopol based methotrexate loaded mucoadhesive microparticles for colon delivery: An in vitro evaluation

Methotrexate (MTX) is famous for its therapeutic potential against different cancers including colorectal cancer. Goal of the present investigation was to formulate MTX loaded mucoadhesive microparticles for colon targeting. The optimized formulation (MTX-MS2) was composed of mucoadhesive polymers (...

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Principais autores: Rohitas Deshmukh, Ranjit K Harwansh, Md. Akhlaquer Rahman
Formato: Artigo
Idioma:Inglês
Publicado em: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas 2021-11-01
coleção:Brazilian Journal of Pharmaceutical Sciences
Assuntos:
Methotrexate
Mucoadhesive microparticles
Colorectal cancer
Sodium alginate
Guargum
Colon
Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100546&tlng=en
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