Hypoxia-altered cholesterol homeostasis enhances the expression of interferon-stimulated genes upon SARS-CoV-2 infections in monocytes

Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases. We characterized the impact of hypoxia on the immunometabolic cross-talk between cholesterol and interferon (IFN) responses. Specifically, hypoxia reduced cholesterol biosynthesis flux and provo...

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Detalhes bibliográficos

Principais autores:	Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Megan A. Palmer, Vanesa Maria Guerrero Ruiz, Giulia Cardamone, Silvia Rösser, Milou Heffels, Fabian Roesmann, Alexander Wilhelm, Dieter Lütjohann, Kathi Zarnack, Dominik Christian Fuhrmann, Marek Widera, Tobias Schmid, Bernhard Brüne
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2023-06-01
coleção:	Frontiers in Immunology
Assuntos:	hypoxia immunometabolism cholesterol SREBP2 COVID-19 systemic inflammation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121864/full
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