Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model

Maternal hypothyroidism is associated with fetal growth restriction, placental dysfunction, and reduced kisspeptin/Kiss1R at the maternal-fetal interface. Kisspeptin affects trophoblastic migration and has antioxidant and immunomodulatory activities. This study aimed to evaluate the therapeutic pote...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Bianca Reis Santos, Jeane Martinha dos Anjos Cordeiro, Luciano Cardoso Santos, Erikles Macedo Barbosa, Letícia Dias Mendonça, Emilly Oliveira Santos, Isabella Oliveira de Macedo, Mário Sergio Lima de Lavor, Raphael Escorsim Szawka, Rogeria Serakides, Juneo Freitas Silva
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2022-07-01
Schriftenreihe:	Frontiers in Endocrinology
Schlagworte:	kisspeptin trophoblast thyroid cell stress inflammation fetal development
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fendo.2022.908240/full
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