Cancer‐associated fibroblast‐derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib

Abstract Background Cancer‐associated fibroblasts (CAFs) play an important role in the induction of chemo‐resistance. This study aimed to clarify the mechanism underlying CAF‐mediated resistance to two tyrosine kinase inhibitors (TKIs), sorafenib and lenvatinib, and to identify a novel therapeutic t...

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Auteurs principaux:	Jung Woo Eun, Jung Hwan Yoon, Hye Ri Ahn, Seokhwi Kim, Young Bae Kim, Su Bin Lim, Won Park, Tae Wook Kang, Geum Ok Baek, Moon Gyeong Yoon, Ju A Son, Ji Hyang Weon, Soon Sun Kim, Hyo Jung Cho, Jae Youn Cheong
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2023-04-01
Collection:	Cancer Communications
Sujets:	drug resistance epithelial‐to‐mesenchymal transition hepatocellular carcinoma secreted phosphoprotein 1
Accès en ligne:	https://doi.org/10.1002/cac2.12414
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