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Human alveolar progenitors generate dual lineage bronchioalveolar organoids

The GSK3 inhibitor CHIR99021 is required to maintain the alveolar lineage in alveolar progenitors grown in airway media or AT2 cells become plastic, with the observed effects acting outside of its role as a GSK3B inhibitor.

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Principais autores: Karen Hoffmann, Benedikt Obermayer, Katja Hönzke, Diana Fatykhova, Zeynep Demir, Anna Löwa, Luiz Gustavo Teixeira Alves, Emanuel Wyler, Elena Lopez-Rodriguez, Maren Mieth, Morris Baumgardt, Judith Hoppe, Theresa C. Firsching, Mario Tönnies, Torsten T. Bauer, Stephan Eggeling, Hong-Linh Tran, Paul Schneider, Jens Neudecker, Jens C. Rückert, Achim D. Gruber, Matthias Ochs, Markus Landthaler, Dieter Beule, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke, Mirjana Kessler
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-08-01
coleção:Communications Biology
Acesso em linha:https://doi.org/10.1038/s42003-022-03828-5
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