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Pleiotropic Effects of Atorvastatin Result in a Downregulation of the Carboxypeptidase U System (CPU, TAFIa, CPB2) in a Mouse Model of Advanced Atherosclerosis

Statins (hydroxymethyl-glutaryl-CoA-reductase inhibitors) lower procarboxypeptidase U (proCPU, TAFI, proCPB2). However, it is challenging to prove whether this is a lipid or non-lipid-related pleiotropic effect, since statin treatment decreases cholesterol levels in humans. In apolipoprotein E-defic...

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Main Authors: Karen Claesen, Lynn Roth, Joachim C. Mertens, Karlijn Hermans, Yani Sim, Dirk Hendriks
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
thrombin activatable fibrinolysis inhibitor
carboxypeptidase B2
HMG-CoA reductase inhibitors
animal models
carboxypeptidase U
fibrinolysis
Online Access:https://www.mdpi.com/1999-4923/13/10/1731
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