A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

Histone lysine-to-methionine (K-to-M) mutations are associated with multiple cancers, and they function in a dominant fashion to block the methylation of corresponding lysines on wild type histones. However, their mechanisms of function are controversial. Here we show that in fission yeast, introduc...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Chun-Min Shan, Jiyong Wang, Ke Xu, Huijie Chen, Jia-Xing Yue, Stuart Andrews, James J Moresco, John R Yates III, Peter L Nagy, Liang Tong, Songtao Jia
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	eLife Sciences Publications Ltd 2016-09-01
Цуврал:	eLife
Нөхцлүүд:	histone methylation K-to-M heterochromatin H3K9M methyltransferase
Онлайн хандалт:	https://elifesciences.org/articles/17903
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!