Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control

Abstract Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle biogenesis and quality control. We have previously...

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Hlavní autoři:	Wagner S. Dantas, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Z. Elizabeth Floyd, Yongmei Yu, Hisashi Fujioka, Charles L. Hoppel, Kathryn P. Belmont, Christopher L. Axelrod, John P. Kirwan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2022-06-01
Edice:	Journal of Cachexia, Sarcopenia and Muscle
Témata:	Sarcopenia Obesity Ageing Bioenergetics Mitochondrial uncoupling BAM15
On-line přístup:	https://doi.org/10.1002/jcsm.12982
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