Transcriptional analysis of primary ciliary dyskinesia airway cells reveals a dedicated cilia glutathione pathway

Primary ciliary dyskinesia (PCD) is a genetic condition that results in dysmotile cilia. The repercussions of cilia dysmotility and gene variants on the multiciliated cell remain poorly understood. We used single-cell RNA-Seq, proteomics, and advanced microscopy to compare primary culture epithelial...

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Detalles Bibliográficos

Principais autores:	Jeffrey R. Koenitzer, Deepesh Kumar Gupta, Wang Kyaw Twan, Huihui Xu, Nicholas Hadas, Finn J. Hawkins, Mary Lou Beermann, Gervette M. Penny, Nathan T. Wamsley, Andrew Berical, Michael B. Major, Susan K. Dutcher, Steven L. Brody, Amjad Horani
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical investigation 2024-09-01
Series:	JCI Insight
Assuntos:	Cell biology Pulmonology
Acceso en liña:	https://doi.org/10.1172/jci.insight.180198
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