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FAPα+ Macrophages Orchestrate Immune Evasion in Multiple Myeloma by Dual Regulation of PD‐L1 and T Cell Senescence

ABSTRACT Multiple myeloma (MM) is a hematologic malignancy driven by clonal expansion of malignant plasma cells. Despite the long‐term disease control achieved with immunotherapies in some patients, treatment resistance remains a major cause of disease relapse. Accumulating evidence highlights the t...

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Principais autores: Huiyao Gu, Zhenfeng Dai, Xi Huang, Enfan Zhang, Xinyuan Dai, Haoguang Chen, Wen Cao, Jinna Zhang, Yifan Hou, Haimeng Yan, Yang Yang, Li Yang, Yi Li, Wenlong Lin, Zhen Cai, Jingsong He
Formato: Artigo
Idioma:Inglês
Publicado: Wiley 2026-03-01
Series:Advanced Science
Assuntos:
FAPα
immune escape
immunotherapy
macrophage
multiple myeloma
PD‐L1
Acceso en liña:https://doi.org/10.1002/advs.202506239
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