Mild expression differences of MECP2 influencing aggressive social behavior

Abstract The X‐chromosomal MECP2/Mecp2 gene encodes methyl‐CpG‐binding protein 2, a transcriptional activator and repressor regulating many other genes. We discovered in male FVB/N mice that mild (~50%) transgenic overexpression of Mecp2 enhances aggression. Surprisingly, when the same transgene was...

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Autors principals:	Martesa Tantra, Christian Hammer, Anne Kästner, Liane Dahm, Martin Begemann, Chiranjeevi Bodda, Kurt Hammerschmidt, Ina Giegling, Beata Stepniak, Aracely Castillo Venzor, Bettina Konte, Begun Erbaba, Annette Hartmann, Asieh Tarami, Walter Schulz‐Schaeffer, Dan Rujescu, Ashraf U Mannan, Hannelore Ehrenreich
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2014-03-01
Col·lecció:	EMBO Molecular Medicine
Matèries:	genetic background human microRNA mouse phenotype‐based genetic association study
Accés en línia:	https://doi.org/10.1002/emmm.201303744
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