Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo

<p>Abstract</p> <p>Background</p> <p>The cationic lipid Genzyme lipid (GL) 67 is the current "gold-standard" for <it>in vivo </it>lung gene transfer. Here, we assessed, if GL67 mediated uptake of siRNAs and asODNs into airway epithelium <it>in vivo</it>.</p> <p>Methods</p> <p>Anti-lacZ and ENaC (epi...

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Detalhes bibliográficos

Principais autores:	Hu Jim, Chow Yu-Hua, Hyde Stephen C, Gill Deborah R, Smith Rbecca L, Painter Hazel, Somerton Luci, Singh Charanjit, Farley Raymond, Garcia Sara, Kitson Chris, Griesenbach Uta, Gray Mike, Edbrooke Mark, Ogilvie Varrie, MacGregor Gordon, Scheule Ronald K, Cheng Seng H, Caplen Natasha J, Alton Eric WFW
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2006-02-01
Colecção:	Respiratory Research
Acesso em linha:	http://respiratory-research.com/content/7/1/26
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