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Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state

Abstract Vestibular schwannomas (VS) are benign tumors that lead to significant neurologic and otologic morbidity. How VS heterogeneity and the tumor microenvironment (TME) contribute to VS pathogenesis remains poorly understood. In this study, we perform scRNA-seq on 15 VS, with paired scATAC-seq (...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Thomas F. Barrett, Bhuvic Patel, Saad M. Khan, Riley D. Z. Mullins, Aldrin K. Y. Yim, Sangami Pugazenthi, Tatenda Mahlokozera, Gregory J. Zipfel, Jacques A. Herzog, Michael R. Chicoine, Cameron C. Wick, Nedim Durakovic, Joshua W. Osbun, Matthew Shew, Alex D. Sweeney, Akash J. Patel, Craig A. Buchman, Allegra A. Petti, Sidharth V. Puram, Albert H. Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-01-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-023-42762-w
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