Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
Abstract The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair. The RAD51-binding TR2 motif at the BRCA2 C-terminus is essential for protection and restart of stalled replication forks. Biochemical evid...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2023-11-01
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| Collection: | Nature Communications |
| Accès en ligne: | https://doi.org/10.1038/s41467-023-42830-1 |
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