Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms

Previously, ceramide-1-phosphate (C1P) and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] were demonstrated to be potent and specific activators of group IVA cytosolic phospholipase A2 (cPLA2α). In this study, we hypothesized that these anionic lipids functionally activated the enzyme by distinct...

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Autori principali:	Preeti Subramanian, Mohsin Vora, Luciana B. Gentile, Robert V. Stahelin, Charles E. Chalfant
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2007-12-01
Serie:	Journal of Lipid Research
Soggetti:	ceramide-1-phosphate ceramide kinase eicosanoids prostaglandins inflammation surface dilution kinetics
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520429219
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