Diagnosis and mitigation of the systemic impact of genome reduction in Escherichia coli DGF-298

ABSTRACT Microorganisms with simplified genomes represent interesting cell chassis for systems and synthetic biology. However, genome reduction can lead to undesired traits, such as decreased growth rate and metabolic imbalances. To investigate the impact of genome reduction on Escherichia coli stra...

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Principais autores:	Antoine Champie, Jean-Christophe Lachance, Anand Sastry, Dominick Matteau, Colton J. Lloyd, Frédéric Grenier, Cameron R. Lamoureux, Simon Jeanneau, Adam M. Feist, Pierre-Étienne Jacques, Bernhard O. Palsson, Sébastien Rodrigue
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology 2024-10-01
Serija:	mBio
Teme:	Escherichia coli systems biology genome-scale metabolic model simplified genome oxidative stress
Online dostop:	https://journals.asm.org/doi/10.1128/mbio.00873-24
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