Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells

Glioblastoma is a highly lethal cancer for which novel therapeutics are urgently needed. Two distinct subtypes of glioblastoma stem-like cells (GSCs) were recently identified: mesenchymal (MES) and proneural (PN). To identify mechanisms to target the more aggressive MES GSCs, we combined transcripto...

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Detalhes bibliográficos

Principais autores:	Peng Cheng, Emma Phillips, Sung-Hak Kim, David Taylor, Thomas Hielscher, Laura Puccio, Anita B. Hjelmeland, Peter Lichter, Ichiro Nakano, Violaine Goidts
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-05-01
coleção:	Stem Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2213671115000995
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