Quantifying the relationship and contribution of mitochondrial respiration to systemic exercise limitation in heart failure

Abstract Aims Heart failure with reduced ejection fraction (HFrEF) induces skeletal muscle mitochondrial abnormalities that contribute to exercise limitation; however, specific mitochondrial therapeutic targets remain poorly established. This study quantified the relationship and contribution of dis...

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Autors principals:	Pim Knuiman, Sam Straw, John Gierula, Aaron Koshy, Lee D. Roberts, Klaus K. Witte, Carrie Ferguson, Thomas Scott Bowen
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 2021-04-01
Col·lecció:	ESC Heart Failure
Matèries:	Exercise HFrEF Lactate threshold Skeletal muscle V̇O2peak
Accés en línia:	https://doi.org/10.1002/ehf2.13272
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