Screening and Identification of a Novel Anti-tuberculosis Compound That Targets Deoxyuridine 5′-Triphosphate Nucleotidohydrolase

Tuberculosis (TB) is still a threat to humans worldwide. The rise of drug-resistant TB strains has escalated the need for developing effective anti-TB agents. Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) is essential for thymidylate biosynthesis to maintain the DNA integrity. In Mycoba...

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Principais autores:	Yu Zhang, Hongjuan Zhang, Ying Chen, Luyao Qiao, Yanxing Han, Yuan Lin, Shuyi Si, Jian-Dong Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-10-01
coleção:	Frontiers in Microbiology
Assuntos:	anti-tuberculosis dUTPase high-throughput screening inhibitor molecular docking
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.757914/full
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