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Steering the course of CAR T cell therapy with lipid nanoparticles

Abstract Lipid nanoparticles (LNPs) have proven themselves as transformative actors in chimeric antigen receptor (CAR) T cell therapy, surpassing traditional methods and addressing challenges like immunogenicity, reduced toxicity, and improved safety. Promising preclinical results signal a shift tow...

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Principais autores: Muhammad Babar Khawar, Ali Afzal, Yue Si, Haibo Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-06-01
Serier:Journal of Nanobiotechnology
Fag:
Chimeric antigen receptor
Lipid nanoparticles
Immunotherapy
mRNA delivery
Nonviral transduction
Online adgang:https://doi.org/10.1186/s12951-024-02630-1
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