Molecular mechanisms of MYCN-dependent apoptosis and the MDM2-p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN amplified neuroblastoma

The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mechanisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14ARF, significantly contribute to this event highlighting p53 reactivatio...

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Detalhes bibliográficos

Principais autores:	Marialaura ePetroni, Veronica eVeschi, Alberto eGulino, Giuseppe eGiannini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2012-10-01
coleção:	Frontiers in Oncology
Assuntos:	Neuroblastoma p53 MDM2 HIPK2 MYCN HMGA1a
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00141/full
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