Transgene expression knock-down in recombinant Modified Vaccinia virus Ankara vectors improves genetic stability and sustained transgene maintenance across multiple passages

Modified vaccinia virus Ankara is a versatile vaccine vector, well suited for transgene delivery, with an excellent safety profile. However, certain transgenes render recombinant MVA (rMVA) genetically unstable, leading to the accumulation of mutated rMVA with impaired transgene expression. This rep...

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書誌詳細

主要な著者:	Patrick Neckermann, Madlen Mohr, Martina Billmeier, Alexander Karlas, Ditte R. Boilesen, Christian Thirion, Peter J. Holst, Ingo Jordan, Volker Sandig, Benedikt Asbach, Ralf Wagner
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2024-02-01
シリーズ:	Frontiers in Immunology
主題:	MVA poxviral vectors Modified Vaccinia Ankara transgene stability transgene knock-down viral vaccines
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1338492/full
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