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Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation. However, the number of receptor dimer pairings occurring in nature is limited to those driven by na...

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Principais autores: Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2017-05-01
coleção:eLife
Assuntos:
cytokine signaling
cytokine engineering
cytokine therapies
Acesso em linha:https://elifesciences.org/articles/22882
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