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The Flavonoid Rutin Enhances Temozolomide Sensitivity in Glioblastoma Spheroids by Modulating Chemoresistance via PI3K/AKT, STAT3, Redox and Kynurenine Pathways, and Altering ECM Remodeling Associated with Reduced Migration

Introduction: Glioblastoma (GBM) is the most aggressive primary tumor of the central nervous system and is highly resistant to temozolomide (TMZ). Rutin is a potent antioxidant with immunomodulatory and anti-glioma effects in vitro, although its mechanisms of action remain incompletely understood. T...

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Principais autores: Irlã Santos Lima, Fernanda Vidal Carvalho, Érica Novaes Soares, Monique Reis de Santana, Maria de Fátima Dias Costa, Carolina Kymie Vasques Nonaka, Bruno Solano de Freitas Souza, Henning Ulrich, Cleonice Creusa dos Santos, Silvia Lima Costa
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-05-01
Serier:Antioxidants
Fag:
glioblastoma
rutin
oxidative stress
kynurenine metabolism
temozolomide
microtumors
Online adgang:https://www.mdpi.com/2076-3921/15/5/643
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