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RMC-6272, a selective third-generation bi-steric mTORC1 inhibitor, improves cardiac function in pressure overload-induced cardiac hypertrophy

Pathological remodeling in cardiomyocytes during heart failure is driven by excessive activation of mTORC1. Preclinical studies in mice demonstrated that reducing mTORC1 activity protects against cardiac dysfunction and hypertrophic remodeling. However, clinical application of current mTOR inhibitor...

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Principais autores: Mariam Rogge, Johannes Fischer, Tobias Jakobi, Zoe Loewenthal, Parul Gupta, Lonny Jürgensen, Norbert Frey, Christoph Sandmann, Mirko Völkers
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-06-01
coleção:Journal of Molecular and Cellular Cardiology Plus
Assuntos:
mTOR
mTORC1
Cardiac hypertrophy
Heart failure
Heart diseases
RMC-6272
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2772976126000140
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