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Biosynthesis of Akaeolide and Lorneic Acids and Annotation of Type I Polyketide Synthase Gene Clusters in the Genome of Streptomyces sp. NPS554

The incorporation pattern of biosynthetic precursors into two structurally unique polyketides, akaeolide and lorneic acid A, was elucidated by feeding experiments with 13C-labeled precursors. In addition, the draft genome sequence of the producer, Streptomyces sp. NPS554, was performed and the biosy...

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Principais autores: Tao Zhou, Hisayuki Komaki, Natsuko Ichikawa, Akira Hosoyama, Seizo Sato, Yasuhiro Igarashi
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2015-01-01
Serier:Marine Drugs
Fag:
polyketide
marine actinomycete
Streptomyces
biosynthesis
genome
Online adgang:http://www.mdpi.com/1660-3397/13/1/581
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