Antibodies against polysaccharide type 3 and pneumococcal proteins demonstrate synergistic protective effect in a highly virulent type 3 invasive disease model in mice

Streptococcus pneumoniae serotype-3 (ST-3) continues to be a major contributor to pneumococcal disease burden despite its inclusion in multivalent pneumococcal conjugate vaccines (PCV). Therefore, there is a pressing need to develop vaccines that can elicit more versatile immune responses against ST...

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Autori principali:	Taylor C. Stevenson, Heidi Burke, Sara E. Roggensack, Anthony Pratt, Aquib Hossain, Pallab Ghosh, Gilles Besin, Yingjie Lu, Fan Zhang, Richard Malley, Shite Sebastian
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-12-01
Serie:	Frontiers in Immunology
Soggetti:	Streptococcus pneumoniae (pneumococcus) serotype 3 vaccine MAPS pneumolysin
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1707686/full
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