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More epigenetic hits than meets the eye: microRNAs and genes associated with the tumorigenesis of retinoblastoma

Retinoblastoma (RB), a childhood neoplasia of the retinoblasts, can occur unilaterally or bilaterally, with one or multiple foci per eye. RB is associated with somatic loss-of-function of both alleles of the tumor suppressor gene RB1. Hereditary forms emerge due to germline loss-of-function mutation...

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Autors principals: Adriana H.O. Reis, Fernando R. Vargas, Bernardo eLemos
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2012-12-01
Col·lecció:Frontiers in Genetics
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Accés en línia:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00284/full
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