Widespread gene transfer in the central nervous system of cynomolgus macaques following delivery of AAV9 into the cisterna magna

Adeno-associated virus serotype 9 (AAV9) vectors have recently been shown to transduce cells throughout the central nervous system of nonhuman primates when injected into the cerebrospinal fluid (CSF), a finding which could lead to a minimally invasive approach to treat genetic and acquired diseases...

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Autors principals:	Christian Hinderer, Peter Bell, Charles H Vite, Jean-Pierre Louboutin, Rebecca Grant, Erin Bote, Hongwei Yu, Bryan Pukenas, Robert Hurst, James M Wilson
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2014-01-01
Col·lecció:	Molecular Therapy: Methods & Clinical Development
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2329050116301206
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