A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target

Abstract Background Merkel cell carcinomas (MCCs) are rare, aggressive, therapeutically-challenging skin tumours that are increasing in incidence and have poor survival rates. The majority are caused by genomic Merkel cell polyomavirus (MCPyV) integration and MCPyV T-antigen expression. Recently, a...

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Autori principali:	Lucia Cappabianca, Stefano Guadagni, Rita Maccarone, Michela Sebastiano, Alessandro Chiominto, Antonietta Rosella Farina, Andrew Reay Mackay
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-10-01
Serie:	Journal of Experimental & Clinical Cancer Research
Soggetti:	Merkel cell carcinoma Merkel cell polyomavirus MCPyV large T-antigen Alternative TrkAIII splicing Oncogenic activation mechanism Therapeutic target
Accesso online:	http://link.springer.com/article/10.1186/s13046-019-1425-3
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