Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel <i>N,N</i>-dimethylglycine ester derivat...

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Váldodahkkit:	Shuichi Setoguchi, Ryoji Hidaka, Nami Nagata-Akaho, Daisuke Watase, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2020-01-01
Ráidu:	Molecules
Fáttát:	bioavailability coenzyme q<sub>10</sub> drug delivery system prodrug ubiquinol ubiquinone
Liŋkkat:	https://www.mdpi.com/1420-3049/25/3/546
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