CD96 marks a phenotypically distinct checkpoint-associated HCV-specific CD8+ T-cell subset featuring memory-associated states

IntroductionHepatitis C virus (HCV) infection frequently progresses to chronicity, where persistent antigen exposure drives differentiation of virus-specific CD8+ T cells toward an exhausted phenotype. This state is defined by progressive upregulation of inhibitory receptors and functional impairmen...

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Hlavní autoři:	Maximilian Knapp, Christin Ackermann, Melanie Wittner, Claudia Beisel, Leon Cords, Tim Westphal, Liz Lam, Silke Kummer, Robin Woost, Sven Peine, Sven Pischke, Christoph Schultheiß, Ansgar W. Lohse, Andreas Walker, Jörg Timm, Mascha Binder, Julian Schulze zur Wiesch
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-07-01
Edice:	Frontiers in Immunology
Témata:	CD8+ T cells CD96 (TACTILE) hepatitis C virus (HCV) immune checkpoint T-cell exhaustion
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1883007/full
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