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Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

Abstract Insulin‐like growth factor 2 (IGF2) and the transformation related protein 53 (Trp53) are potent regulators of cell growth and metabolism in development and cancer. In vitro evidence suggests several mechanistic pathway interactions. Here, we tested whether loss of function of p53 leads to...

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Autores principales: Victoria L. Haley, David J. Barnes, Ionel Sandovici, Miguel Constancia, Christopher F. Graham, Francesco Pezzella, Claudia Bühnemann, Emma J. Carter, A. Bassim Hassan
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Nature 2012-06-01
Colección:EMBO Molecular Medicine
Materias:
embryogenesis
Igf2
p53
tumour predisposition
X‐linked
Acceso en línea:https://doi.org/10.1002/emmm.201101105
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