Protein–Protein Interactions Mediated by Intrinsically Disordered Protein Regions Are Enriched in Missense Mutations

Because proteins are fundamental to most biological processes, many genetic diseases can be traced back to single nucleotide variants (SNVs) that cause changes in protein sequences. However, not all SNVs that result in amino acid substitutions cause disease as each residue is under different structu...

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Principais autores:	Eric T. C. Wong, Victor So, Mike Guron, Erich R. Kuechler, Nawar Malhis, Jennifer M. Bui, Jörg Gsponer
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-07-01
coleção:	Biomolecules
Assuntos:	intrinsically disordered proteins single nucleotide variants protein–protein interactions interface core and rim human disease
Acesso em linha:	https://www.mdpi.com/2218-273X/10/8/1097
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