Monoacylated Cellular Prion Proteins Reduce Amyloid-β-Induced Activation of Cytoplasmic Phospholipase A2 and Synapse Damage

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid-β (Aβ) and the loss of synapses. Aggregation of the cellular prion protein (PrPC) by Aβ oligomers induced synapse damage in cultured neurons. PrPC is attached to membranes via a glycosylp...

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Hlavní autoři:	Ewan West, Craig Osborne, William Nolan, Clive Bate
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2015-06-01
Edice:	Biology
Témata:	Alzheimer’s disease amyloid-β glycosylphosphatidylinositols prion synapses synaptophysin
On-line přístup:	http://www.mdpi.com/2079-7737/4/2/367
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