Modification of 4-(4-chlorothiophen-2-yl)thiazol-2-amine derivatives for the treatment of analgesia and inflammation: synthesis and in vitro, in vivo, and in silico studies

Inflammation is a protective response to a variety of infectious agents. To develop a new anti-inflammatory drug, we explored a pharmacologically important thiazole scaffold in this study. In a multi-step synthetic approach, we synthesized seven new thiazole derivatives (5a–5g). Initially, we examin...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Mater H. Mahnashi, Umer Rashid, Hassan Hussain Almasoudi, Mohammed H. Nahari, Imran Ahmad, Abdulkarim S. Binshaya, Osama Abdulaziz, Meshari A. Alsuwat, Muhammad Saeed Jan, Abdul Sadiq
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-02-01
Schriftenreihe:	Frontiers in Pharmacology
Schlagworte:	analgesic inflammation thiazole cyclooxygenase LOX in vivo mechanism
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1366695/full
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