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Azacitidine as maintenance therapy in pediatric de novo acute myeloid leukemia

BackgroundRelapse remains a major challenge in pediatric acute myeloid leukemia (AML), particularly in patients ineligible for hematopoietic stem cell transplantation (HSCT). Hypomethylating agents like azacitidine are hypothesized to target residual disease, but their efficacy and safety as mainten...

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Principais autores: Chunping Wu, Chunxia Cai, Mei Li, Nainong Li, Yongzhi Zheng, Hao Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-12-01
coleção:Frontiers in Immunology
Assuntos:
pediatric AML
azacitidine maintenance
measurable residual disease
molecular relapse
risk stratification
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1696125/full
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