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Astragaloside IV — mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis

INTRODUCTION: As one of the basic components of Astragalus, Astragaloside IV (AS-IV) has a protective effect on endothelial injury caused by diabetes. AS-IV stimulated endothelial progenitor cells (EPCs) to secrete exosomes loaded with miR-21. This study aimed to investigate the effects of AS-IV-med...

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Autori principali: Wu Xiong, Xin-ling Huang, Cheng-yu Li, Xiao-liang Wang, Hong-wei Lan, Ting-ting Wang, Zi-lin Chen, Qian-pei Yang, Ai-lin Hu, Yi-fei Xia, Fu-rong Zhu, Zhong-zhi Zhou
Natura: Artigo
Lingua:Inglês
Pubblicazione: Via Medica 2022-12-01
Serie:Folia Histochemica et Cytobiologica
Soggetti:
astragaloside (AS-IV)
endothelial progenitor cells (EPCs)
exosomes
HUVECs
miR-21/PTEN
autophagy
apoptosis
Accesso online:https://journals.viamedica.pl/folia_histochemica_cytobiologica/article/view/89838
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