The entactogen MDMA (3,4-methylenedioxymethamphetamine, “Ecstasy”) disrupts helping behaviour while reinforcing electrophysiological indicators of potentially associated synaptic plasticity in male Sprague-Dawley rats

IntroductionIn humans, empathy is expressed through various prosocial behaviours between individuals that may be enhanced after intake of the synthetic entactogen MDMA (3,4-methylenedioxymethamphetamine, “Ecstasy”) as the behavioural expression of the so-called entactogenic syndrome. Rodents may als...

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Detalhes bibliográficos

Principais autores:	Patricio Sáez-Briones, Amanda Silva-Rodríguez, Michelle Morales-Vidal, Yaniz Sepúlveda-Fernández, Dorys Jara-Clen, Michelle Castro-Choapa, Pablo Livacic-Rojas, Darío Martínez-Afani, Bruce K. Cassels, Rafael Barra, Luis Constandil, Jeffri Retamal, Alejandro Hernández
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Pharmacology
Assuntos:	3,4-methylenedioxymethamphetamine helping behaviour LTD (long term depression) LTP (long term potentiation) serotonin oxytocin
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1779772/full
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