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Development of a PRAME pMHC targeted T cell engager for solid tumor therapy

Bispecific T cell engager (TCE) therapies have demonstrated transformative clinical success in the treatment of hematological cancers, but the lack of antigens that are sufficiently selective for malignant cells has hampered the success of TCEs in the solid-tumor space. To overcome the on-target, of...

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Uloženo v:
Hlavní autoři: Katarzyna Skrzypczynska, Kristin Schimert, Heather Stephenson, In Kyoung Mah, David Mortenson, Kelli Boyd, Timothy Hardman, Nikolai Novikov, Elbert Seto, Sabrina Lu, Randy Yen, Brian Lee, Min Wang, Don Kang, Ying Huang, Xinchao Yu, Magdeleine Hung, Sheng Ding, Nathan Thomsen, Nicole Schirle Oakdale
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis Group 2025-12-01
Edice:mAbs
Témata:
PRAME
TCR-mimic (TCRm) antibody
T cell engager
solid tumor
Cancer testes antigen
pMHC complex
On-line přístup:https://www.tandfonline.com/doi/10.1080/19420862.2025.2563773
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