Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is not completely known. Here, the authors show that reciprocal inhibition between Cdh1 and the c-Src signaling pathway regulate breast cancer tumorigenesis.

Dades bibliogràfiques

Autors principals:	Tao Han, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, Su Jung Song, Amer A. Beg, Pier Paolo Pandolfi, Lixin Wan
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2019-08-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-019-11618-7
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