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Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways

AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin (GFX) to stromal fibroblasts (SFs) in vitro. METHODS: SFs were treated with GFX at different concentrations (0.009375%-0.3%), and their viability was detected by MTT method. The cell morphology was observed using light/transmiss...

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Principais autores: Bin Xu, Yun-Long Sui, Ting-Jun Fan
Formato: Artigo
Idioma:Inglês
Publicado em: Press of International Journal of Ophthalmology (IJO PRESS) 2019-10-01
coleção:International Journal of Ophthalmology
Assuntos:
gatifloxacin
stromal fibroblasts
cytotoxicity
apoptosis
caspase
extrinsic pathway
intrinsic pathway
Acesso em linha:http://www.ijo.cn/en_publish/2019/10/20191002.pdf
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