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Human placental extract ameliorates methotrexate-induced nephrotoxicity in albino rats: ultrastructural, biochemical and biophysical studies

Abstract Methotrexate (MTX) is a well-known medication for the treatment of different cancer types and autoimmune diseases. The current study target was to measure the capability of human placental extract (HPE) to ameliorate the nephrotoxicity induced by MTX in male albino rats. In the present stud...

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Main Authors: Hoda A. Mahran, Yasmeen M. Gawaan, Mohamed SA. El-Gerbed, Yasser I. Khedr
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-06-01
Series:Scientific Reports
Subjects:
Methotrexate
Human placental extract
Nephrotoxicity
Anti-oxidants
Ultrastructure
Rats
Online Access:https://doi.org/10.1038/s41598-026-55946-3
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