MYB represses ζ-globin expression through upregulating ETO2

Reactivating the embryonic ζ-globin gene represents a potential therapeutic approach to ameliorate the severe clinical phenotype of α-thalassemia and sickle cell disease. The transcription factor MYB has been extensively proven to be a master regulator of the γ-globin gene, but its role in the regul...

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Principais autores:	Dong Zejun, Ye Yuhua, Zhang Wei, Luo Hualei, Li Jialong, Zhang Qianqian, Zhang Xinhua, Guo Xiang, Xu Xiangmin
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	China Science Publishing & Media Ltd. 2025-01-01
סדרה:	Acta Biochimica et Biophysica Sinica
נושאים:	gene switch thalassemia hematopoiesis zeta-globin
גישה מקוונת:	https://www.sciengine.com/doi/10.3724/abbs.2024239
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