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Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation

Perturbed Nicotinamide adenine dinucleotide (NAD+) homeostasis is involved in cancer progression and metastasis. Quinolinate phosphoribosyltransferase (QPRT) is the rate-limiting enzyme in the kynurenine pathway participating in NAD+ generation. In this study, we demonstrated that QPRT expression wa...

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Principais autores: Chien-Liang Liu, Shih-Ping Cheng, Ming-Jen Chen, Chi-Hsin Lin, Shan-Na Chen, Yi-Hue Kuo, Yuan-Ching Chang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-02-01
Serier:Frontiers in Endocrinology
Fag:
quinolinate phosphoribosyltransferase
NAD
myosin light chain
neoplasm invasiveness
breast cancer
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2020.621944/full
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