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Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors

Cyclin-dependent kinases (CDKs) constitute a family of 20 serine/threonine protein kinases that play pivotal roles in the regulation of numerous important molecular and cellular processes. CDKs have long been considered promising therapeutic targets in a variety of pathologies, and the recent therap...

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Principais autores: Thomas Robert, Jared L. Johnson, Roxane Guichaoua, Tomer M. Yaron, Stéphane Bach, Lewis C. Cantley, Pierre Colas
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020-02-01
Serija:Frontiers in Chemistry
Teme:
Online dostop:https://www.frontiersin.org/article/10.3389/fchem.2020.00147/full
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