Structural studies of a bacterial tRNA(HIS) guanylyltransferase (Thg1)-like protein, with nucleotide in the activation and nucleotidyl transfer sites.

All nucleotide polymerases and transferases catalyze nucleotide addition in a 5' to 3' direction. In contrast, tRNA(His) guanylyltransferase (Thg1) enzymes catalyze the unusual reverse addition (3' to 5') of nucleotides to polynucleotide substrates. In eukaryotes, Thg1 enzymes use the 3'-5' addition...

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Автори:	Samantha J Hyde, Bhalchandra S Rao, Brian E Eckenroth, Jane E Jackman, Sylvie Doublié
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2013-01-01
Серія:	PLoS ONE
Онлайн доступ:	http://europepmc.org/articles/PMC3701042?pdf=render
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