The Kinetics of Inflammation-Related Proteins and Cytokines in Children Undergoing CAR-T Cell Therapy—Are They Biomarkers of Therapy-Related Toxicities?

CD19-targeted CAR-T cell therapy has revolutionized the treatment of relapsed/refractory (r/r) pre-B acute lymphoblastic leukemia (ALL). However, it can be associated with acute toxicities related to immune activation, particularly cytokine release syndrome (CRS) and immune effector cell-associated...

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Principais autores:	Paweł Marschollek, Karolina Liszka, Monika Mielcarek-Siedziuk, Iwona Dachowska-Kałwak, Natalia Haze, Anna Panasiuk, Igor Olejnik, Tomasz Jarmoliński, Jowita Frączkiewicz, Zuzanna Gamrot, Anna Radajewska, Iwona Bil-Lula, Krzysztof Kałwak
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-07-01
Series:	Biomedicines
Assuntos:	chimeric antigen receptors CAR-T cells CRS ICANS cytokines biomarkers
Acceso en liña:	https://www.mdpi.com/2227-9059/12/7/1622
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