A long-range enhancer at -52Kb drives expression of the COUP-TFII transcription factor in erythroid cells

Abstract COUP-TFII, encoded by the NR2F2 gene, is an orphan nuclear receptor highly expressed during embryonic development in several tissues. In erythropoiesis, COUP-TFII is active in yolk sac-derived cells prior to the switch to adult globin expression. Its broad expression pattern suggests a comp...

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Hlavní autoři:	Valentina Pastori, Agata Labedz, Maria A. Simanovich, Martina Fabiano, Carlotta Frigo, Thijs Verheul, Ludovica Proietti, Florian Grebien, Elisabetta Citterio, Sjaak Philipsen, Antonella Ellena Ronchi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Scientific Reports
On-line přístup:	https://doi.org/10.1038/s41598-026-46308-0
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