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Cutaneous nociceptors lack sensitisation, but reveal μ-opioid receptor-mediated reduction in excitability to mechanical stimulation in neuropathy

<p>Abstract</p> <p>Background</p> <p>Peripheral nerve injuries often trigger a hypersensitivity to tactile stimulation. Behavioural studies demonstrated efficient and side effect-free analgesia mediated by opioid receptors on peripheral sensory neurons. However, mechanistic approaches addressing suc...

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Principais autores: Schmidt Yvonne, Labuz Dominika, Heppenstall Paul A, Machelska Halina
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publishing 2012-11-01
Serier:Molecular Pain
Fag:
Neuropathic pain
Nociceptors
Mechanical sensitivity
Opioids
Online adgang:http://www.molecularpain.com/content/8/1/81
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